tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane
CAS No.:201233-08-1
Molecular Formula:C₂₃H₃₈O₄Si
Molecular Weight:406.638
Hs Code.:

Synonyms:tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

There total 4 articles about tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 201233-06-9
p-tert-Butylphenyl 6-O-(tert-butyldimethylsilyl)-2,3-dideoxy-α-D-threo-hex-2-enopyranoside

: 74-88-4
methyl iodide

: 201233-08-1
tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 25 ℃; for 24h;
DOI:10.1021/jo9714674

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 201233-08-1
tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole, Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) ClCH₂COOH, PPh₃, DEAD, 2.) CH₃ONa / 1.) toluol, 0 deg C, 30 min; room temperature, 24 h, 2.) MeOH, 1 h

3: 90 percent / NaH / tetrahydrofuran / 24 h / 25 °C

With 1H-imidazole; sodium methylate; sodium hydride; triethylamine; chloroacetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9714674

Reference yield:

: 201233-05-8
p-tert-Butylphenyl 6-O-(tert-butyldimethylsilyl)-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside

: 201233-08-1
tert-Butyl-[(2R,3R,6R)-6-(4-tert-butyl-phenoxy)-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) ClCH₂COOH, PPh₃, DEAD, 2.) CH₃ONa / 1.) toluol, 0 deg C, 30 min; room temperature, 24 h, 2.) MeOH, 1 h

2: 90 percent / NaH / tetrahydrofuran / 24 h / 25 °C

With sodium methylate; sodium hydride; chloroacetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jo9714674