(DIFLUOROMETHYL)BENZENE

Base Information

• Chemical Name: (DIFLUOROMETHYL)BENZENE
• CAS No.: 455-31-2
• Molecular Formula: C7H6F2
• Molecular Weight: 128.121
• Hs Code.: 2903999090
• Mol file: 455-31-2.mol

Synonyms:(Difluoromethyl)benzene;Toluene, a,a-difluoro- (6CI,7CI,8CI);a,a-Difluorotoluene;Benzal fluoride;

Chemical Property of (DIFLUOROMETHYL)BENZENE

Chemical Property:

• Refractive Index: n20/D1.458
• Boiling Point: 140 °C at 760 mmHg
• Flash Point: 20.3 °C
• PSA: 0.00000
• Density: 1.091 g/cm³
• LogP: 2.62420

Purity/Quality:

98%,99%, ^*data from raw suppliers

(Difluoromethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 10-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (DIFLUOROMETHYL)BENZENE

There total 86 articles about (DIFLUOROMETHYL)BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzaldehyde (100-52-7) → difluoromethylbenzene (455-31-2)

Guidance literature:

With ethanol; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; for 16h; Heating;

DOI:10.1039/a808517j

Reference yield: 95.0%

2-Phenyl-[1,3]dithiane (5425-44-5) → difluoromethylbenzene (455-31-2)

Guidance literature:

With 4-methylphenylsulfur trifluoride; In dichloromethane; at 20 ℃; for 2h; Product distribution / selectivity;

Reference yield: 90.0%

α,α,α-trifluorotoluene (98-08-8) → difluoromethylbenzene (455-31-2)

Guidance literature:

α,α,α-trifluorotoluene; With 2,4,6-triphenylpyridine; tris(pentafluorophenyl)borate; trimethylsilyl bis(trifluoromethanesulfonyl)imide; In 1,2-dichloro-ethane; at 60 ℃; for 16h;

With benzophenone; sodium 4-fluorophenylthiolate; In 1,2-dichloro-ethane; at 20 ℃; for 16h;

upstream raw materials:

benzylidene dichloride

phenylsulphur trifluoride

benzaldehyde

dibenzyl disulphide

Downstream raw materials:

cyclohexylmethylene difluoride

methyl cyclohexane

benzaldehyde

α-bromo-α-fluorotoluene

Refernces

• 1、 Peel, J. Barrie,Nagy-Felsobuki, Ellak I. Von. "THE PHOTOELECTRON SPECTRA OF THE FLUOROTOLUENES". . p. 195 - 206. Retrieved 1987.
• 2、 Yoshida, Masato,Suzuki, Daiki,Iyoda, Masahiko. "Reductive Conversion of Chlorodifluoromethylbenzene with Samarium(II) Diiodide". . p. 2357 - 2360. Retrieved 1994.
• 3、 -. "A NEW METHOD OF 18F LABELLING AND INTERMEDIATE SALTS". Page/Page column 73. . Retrieved 2021/06/26.
• 4、 -. "METHOD AND REAGENT FOR DEOXYFLUORINATION". Paragraph 0148-0150; 0152; 0159. . Retrieved 2021/05/29.