2-(2-bromophenyl)-N-phenylacetamide

Base Information

• Chemical Name: 2-(2-bromophenyl)-N-phenylacetamide
• CAS No.: 120230-90-2
• Molecular Formula: C₁₄H₁₂BrNO
• Molecular Weight: 290.159
• Mol file: 120230-90-2.mol

Synonyms:2-(2-bromophenyl)-N-phenylacetamide

Chemical Property of 2-(2-bromophenyl)-N-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-bromophenyl)-N-phenylacetamide

There total 9 articles about 2-(2-bromophenyl)-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ortho-bromophenylacetic acid (18698-97-0) + aniline (62-53-3) → 2-(2-bromophenyl)-N-phenylacetamide (120230-90-2)

Guidance literature:

ortho-bromophenylacetic acid; With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 2h;

aniline; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/adsc.201300818

Reference yield: 48.0%

cis-3-(2-bromophenyl)oxirane-2-carbonitrile + aniline (62-53-3) → 2-(2-bromophenyl)-N-phenylacetamide (120230-90-2)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,4-dioxane; at 190 ℃; for 0.5h; Microwave irradiation; Green chemistry;

DOI:10.1039/c9ob02428j

Reference yield: 48.0%

2-(2-bromophenyl)acetonitrile (19472-74-3) + Diphenyliodonium triflate (66003-76-7) → 2-(2-bromophenyl)-N-phenylacetamide (120230-90-2)

Guidance literature:

With copper (I) trifluoromethane sulfonate toluene complex; caesium carbonate; In toluene; at 80 ℃; for 0.333333h;

DOI:10.1039/d1ra02305e

upstream raw materials:

ortho-bromophenylacetic acid

aniline

2-(2-bromophenyl)acetonitrile

3-(2-bromo-phenyl)-2-thioxo-propionic acid

Downstream raw materials:

1-phenyl-1,3-dihydro-indol-2-one

1-phenyl-indole-2,3-dione