2-(3,4-dichlorophenyl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,N-dimethyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyramide

Base Information

Chemical Name:2-(3,4-dichlorophenyl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,N-dimethyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyramide
CAS No.:1131738-29-8
Molecular Formula:C₂₉H₃₃Cl₂F₄N₃O₂
Molecular Weight:602.5
Hs Code.:

Synonyms:2-(3,4-dichlorophenyl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,N-dimethyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyramide

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Chemical Property of 2-(3,4-dichlorophenyl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,N-dimethyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyramide

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Technology Process of 2-(3,4-dichlorophenyl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,N-dimethyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyramide

There total 3 articles about 2-(3,4-dichlorophenyl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,N-dimethyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1131739-64-4
(3-fluoro-4-(trifluoromethyl)benzyl)methylamine, hydrochloride

: 1131739-56-4
2-(3,4-dichlorophenyl)-2-methyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyric acid

: 1131738-29-8
2-(3,4-dichlorophenyl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,N-dimethyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyramide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 42h;
DOI:10.1021/jm900948q

Reference yield: 29.0%

: 1131739-64-4
(3-fluoro-4-(trifluoromethyl)benzyl)methylamine, hydrochloride

: 1131739-60-0
4-[4-(acetyl(methylamino))piperidin-1-yl]-2-(3,4-dichlorophenyl)-2-methylbutyric acid

: 1131738-29-8
2-(3,4-dichlorophenyl)-N-(4-fluoro-3-(trifluoromethyl)benzyl)-2,N-dimethyl-4-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]butyramide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1021/jm900948q