N⁴-anisoyl-2'3'-O-(methyoxymethylene)uridine

Base Information

• Chemical Name: N⁴-anisoyl-2'3'-O-(methyoxymethylene)uridine
• CAS No.: 101977-71-3
• Molecular Formula: C₁₉H₂₀N₂O₉
• Molecular Weight: 420.376
• Mol file: 101977-71-3.mol

Synonyms:N⁴-anisoyl-2'3'-O-(methyoxymethylene)uridine

Chemical Property of N⁴-anisoyl-2'3'-O-(methyoxymethylene)uridine

Chemical Property:

Purity/Quality:

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Technology Process of N⁴-anisoyl-2'3'-O-(methyoxymethylene)uridine

There total 1 articles about N⁴-anisoyl-2'3'-O-(methyoxymethylene)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N3-anisoyluridine (86988-33-2) + trimethyl orthoformate (149-73-5) → N4-anisoyl-2'3'-O-(methyoxymethylene)uridine (101977-71-3)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1055/s-1985-31220

Reference yield: 80.0%

triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydro-2-pyranyl)-N3-(p-anisoyl)uridine 3'-phosphorothioate (86964-80-9) + N4-anisoyl-2'3'-O-(methyoxymethylene)uridine (101977-71-3) → C68H67N4O21PS (101904-13-6)

Guidance literature:

With 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; 3-nitro-1,2,4-triazole; In pyridine;

DOI:10.1016/S0040-4039(00)98768-9

Reference yield:

N4-anisoyl-2'3'-O-(methyoxymethylene)uridine (101977-71-3) → uridylyl-3',5'-uridine (2415-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / mesitylenedisulfonyl chloride, 3-nitro-1,2,4-triazole / pyridine

2: 1.) bis(tributyltin) oxide 2.) trimethylsilyl chloride 3.) ammonia-pyridine 4.) HCl / further tinorganic compounds were used for dephenylthiolation

With chloro-trimethyl-silane; pyridine amine; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; 3-nitro-1,2,4-triazole; bis(tri-n-butyltin)oxide; In pyridine;

DOI:10.1016/S0040-4039(00)98768-9

upstream raw materials:

N³-anisoyluridine

trimethyl orthoformate

Downstream raw materials:

C₆₈H₆₇N₄O₂₁PS

uridylyl-3',5'-uridine