1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane

Base Information

Chemical Name:1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane
CAS No.:85175-75-3
Molecular Formula:C₂₅H₃₀N₂O₅
Molecular Weight:438.524
Hs Code.:

Synonyms:1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane

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Chemical Property of 1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane

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Technology Process of 1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane

There total 6 articles about 1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.2%

: 85175-75-3
1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane

Guidance literature:

Reference yield:

: 6845-81-4
3,4-methylenedioxyphenylacetyl chloride

: 85175-75-3
1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

2: glacial acetic acid, conc. HCl / 17 h / Ambient temperature

3: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

4: 2 h / 90 - 95 °C

With hydrogenchloride; potassium tert-butylate; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm00167a033

Reference yield:

: 2861-28-1
1,3-benzodioxole-5-acetic acid

: 85175-75-3
1-[7,8-Methylenedioxy-1,3-dihydro-2H-3-benzazepin 2-on-3-yl]-3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)-amino]-propane

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / CH₂Cl₂ / 1 h / Heating

2: triethylamine / CH₂Cl₂ / 1 h / Ambient temperature

3: glacial acetic acid, conc. HCl / 17 h / Ambient temperature

4: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min

5: 2 h / 90 - 95 °C

With hydrogenchloride; thionyl chloride; potassium tert-butylate; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm00167a033