1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one

Base Information

Chemical Name:1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one
CAS No.:521092-07-9
Molecular Formula:C₁₄H₁₁FN₄OS
Molecular Weight:302.332
Hs Code.:

Synonyms:1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one

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Chemical Property of 1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one

There total 8 articles about 1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 521092-49-9
2,2-dimethoxy-2-(2-methylsulfanylpyrimidin-4-yl)ethylamine

: 1195-45-5
para-fluorophenyl isocyanate

: 521092-07-9
1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one

Guidance literature:: 2,2-dimethoxy-2-(2-methylsulfanylpyrimidin-4-yl)ethylamine; para-fluorophenyl isocyanate; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 49844-90-8
4-Chloro-2-methylthiopyrimidine

: 521092-07-9
1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 80 °C

1.2: 20 °C

2.1: hydrogenchloride / water; acetone / 1 h / 20 °C

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.5 h / Heating / reflux

4.1: triethylamine / dichloromethane / 20 °C

5.1: tetrahydrofuran / 0 - 20 °C

5.2: 4 h / 0 - 20 °C

6.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

6.2: 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 106157-94-2
1-(dimethylamino)-4,4-dimethoxypent-1-en-3-one

: 521092-07-9
1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol / 3 h / 70 °C

1.2: 1 h / 0 - 20 °C

2.1: water; acetone / 3 h / 0 - 20 °C

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.5 h / Heating / reflux

4.1: triethylamine / dichloromethane / 20 °C

5.1: tetrahydrofuran / 0 - 20 °C

5.2: 4 h / 0 - 20 °C

6.1: tetrahydrofuran / 0.5 h / 0 - 20 °C

6.2: 20 °C

With hydroxylamine hydrochloride; sodium methylate; sodium acetate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetone;