106157-94-2

Basic information

• Product Name: (E)-1-Dimethylamino-4,4-dimethoxy-pent-1-en-3-one
• Synonyms: (E)-1-Dimethylamino-4,4-dimethoxy-pent-1-en-3-one
• CAS NO: 106157-94-2
• Molecular Formula: C₉H₁₇NO₃
• Molecular Weight: 187.23618
• Mol File: 106157-94-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 59-60 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 225.7±40.0 °C(Predicted)
• Appearance: /
• Density: 0.996±0.06 g/cm3(Predicted)
• PKA: 6.52±0.70(Predicted)
• CAS DataBase Reference: (E)-1-Dimethylamino-4,4-dimethoxy-pent-1-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-Dimethylamino-4,4-dimethoxy-pent-1-en-3-one(106157-94-2)
• EPA Substance Registry System: (E)-1-Dimethylamino-4,4-dimethoxy-pent-1-en-3-one(106157-94-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 106157-94-2(Hazardous Substances Data)

Usage

General Description

(E)-1-Dimethylamino-4,4-dimethoxy-pent-1-en-3-one is a chemical compound with the molecular formula C10H19NO3. It is a pale yellow oil with a strong odor and is commonly used in organic synthesis as a reagent and intermediate. (E)-1-Dimethylamino-4,4-dimethoxy-pent-1-en-3-one is known for its potent odor and is often used in perfumery and flavoring applications. It is also used as a precursor in the synthesis of various pharmaceuticals and other organic compounds. Additionally, it is used as a flavoring agent in food products and as a fragrance in personal care products. Overall, (E)-1-Dimethylamino-4,4-dimethoxy-pent-1-en-3-one has a wide range of industrial applications due to its versatile reactivity and odor properties.

Upstream product

• 21983-72-2 3,3-dimethoxy-butan-2-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 521092-13-7 1-(2-cyanobenzyl)-3-(4-fluorophenyl)-4-(2-methylsulfinylpyrimidin-4-yl)-4-imidazolin-2-one 
• 521092-72-8 C₁₆H₁₉FN₄O₅S 
• 521092-71-7 C₁₆H₁₉FN₄O₃S 
• 521092-16-0 1-(4-fluorophenyl)-5-(2-methylsulfinylpyrimidin-4-yl)-4-imidazolin-2-one 
• 521092-46-6 1-(2-methylsulfanylpyrimidin-4-yl)ethanoneoxime tosylate 
• 521087-88-7 1-(2-cyanobenzyl)-3-(4-fluorophenyl)-4-(2-isopropoxypyrimidin-4-yl)-4-imidazolin-2-one 
• 521091-13-4 C₁₆H₁₆FN₅O 
• 521092-64-8 C₁₇H₂₁N₃O₄S 
• 521092-07-9 1-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-4-imidazolin-2-one 
• 496863-48-0 1-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone 
• 106157-82-8 4-Acetyl-2-aminopyrimidine 
• 1009056-19-2 [4-(1,1-dimethoxyethyl)pyrimidin-2-yl]phenylamine 
• 864464-02-8 1-(2-Ethylaminopyrimidin-4-yl)ethanone 
• 521092-35-3 4-(1,1-dimethoxy-ethyl)-2-methylsulfanyl-pyrimidine 

Relevant articles and documents

Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M

One compound sometimes shows two biological functions, becoming important aspect of recent drug discovery. This study began with an attempt to confirm the previously reported molecular mechanism of the anti-human immunodeficiency virus (HIV) heterocyclic compound BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], i.e., induction of abnormal uncoating of the viral core at the post-entry step. Our mechanistic study gave results consistent with this mechanism. We further attempted to find out the molecular target of BMMP by a pulldown approach using previously synthesized biotinylated BMMP (Biotin-BMMP) and successfully identified heterogenous nuclear ribonucleoprotein M (hnRNP M) as a BMMP-binding protein. This protein was found not to be accountable for the anti-HIV activity of BMMP. As hnRNP M has been reported to promote cancer metastasis, we tested this mechanism and found that BMMP suppressed migration of the human lung carcinoma cell line A549 stimulated with transforming growth factor-β (TGF-β). Mechanistic study showed that BMMP suppressed the expression of CD44 mRNA via the regulation of hnRNP M. Furthermore, six new derivatives of BMMP were synthesized, and the patterns of their activities against HIV-1 and cell migration were not uniform, suggesting that the anti-HIV mechanism and the anti-cell migration mechanism of BMMP are independent. Taken together, the anti-cell migration activity of the anti-HIV heterocyclic compound BMMP was newly discovered by identification of its binding protein hnRNP M using a chemical biology approach.

AMINO-HETEROARYL DERIVATIVES AS HCN BLOCKERS

The invention relates to amino-heteroaryl derivatives having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

N-substituted pyrrolopyridinones active as kinase inhibitors

Compounds represented by formula (I) wherein A, R1, R2, R3, R4, R5, and R6 are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.