1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole

Base Information

• Chemical Name: 1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole
• CAS No.: 119935-43-2
• Molecular Formula: C₂₄H₂₁NO₂S
• Molecular Weight: 387.502
• Mol file: 119935-43-2.mol

Synonyms:1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole

Chemical Property of 1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole

There total 3 articles about 1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

1-phenyl-2-bromomethyl-3-acetyl-5-acetoxyindole (119935-39-6) + phenylmethanethiol (100-53-8) → 1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole (119935-43-2)

Guidance literature:

With potassium hydroxide; In ethanol; 1.) room temp., 1 h, 2.) water bath, 2 h;

DOI:10.1007/BF00771642

Reference yield:

1-(5-hydroxy-2-methyl-1-phenyl-1H-indol-3-yl)ethanone (5102-18-1) → 1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole (119935-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 97.7 percent / 3.5 h / Heating

2: 96 percent / NBS / CCl₄ / 1 h / Heating

3: 98.7 percent / KOH / ethanol / 1.) room temp., 1 h, 2.) water bath, 2 h

With potassium hydroxide; N-Bromosuccinimide; In tetrachloromethane; ethanol;

DOI:10.1007/BF00771642

Reference yield:

1-Phenyl-2-methyl-3-acetyl-5-acetoxyindole (119935-38-5) → 1-Phenyl-2-benzylthiomethyl-3-acetyl-5-oxyindole (119935-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / NBS / CCl₄ / 1 h / Heating

2: 98.7 percent / KOH / ethanol / 1.) room temp., 1 h, 2.) water bath, 2 h

With potassium hydroxide; N-Bromosuccinimide; In tetrachloromethane; ethanol;

DOI:10.1007/BF00771642

upstream raw materials:

1-phenyl-2-bromomethyl-3-acetyl-5-acetoxyindole

phenylmethanethiol

1-(5-hydroxy-2-methyl-1-phenyl-1H-indol-3-yl)ethanone

1-Phenyl-2-methyl-3-acetyl-5-acetoxyindole

Downstream raw materials:

1-Phenyl-2-benzylthiomethyl-3-acetyl-4-dimethylaminomethyl-5-oxyindole