5102-18-1Relevant academic research and scientific papers
Montmorillonite clay catalyzed three component, one-pot synthesis of 5-Hydroxyindole derivatives
Reddy, B.V.Subba,Reddy, P. Sivaramakrishna,Reddy, Y. Jayasudhan,Bhaskar,Reddy, B. Chandra Obula
, p. 2968 - 2972 (2014/01/06)
A highly efficient and environmentally benign protocol has been developed for the first time to produce a wide range of biologically active 5-hydroxyindole derivatives using montmorillonite KSF clay as a reusable solid acid catalyst. The use of recyclable clay makes this procedure quite simple, more convenient and cost-effective.
Lewis acid catalyzed Nenitzescu indole synthesis
Velezheva, Valeriya S.,Kornienko, Albert G.,Topilin, Sergey V.,Turashev, Ascar D.,Peregudov, Alexander S.,Brennan, Patrick J.
, p. 873 - 879 (2007/10/03)
A novel method for Lewis acid catalyzed Nenitzescu indole syntheses of 5-hydroxyindoles bearing different substituents in positions 1 (Alk, Bn, Ar), 2 (Me, Et, Ph), and 3 (COOEt, COMe, CONHPh) as well as tricyclic derivatives are reported. The method is simple, rapid, efficient, and allows preparation of hydroxyindoles from 1,4-benzoquinone and enamines in good to excellent yields with the use of low-polar solvents in the presence of weak Lewis acids catalysts. The formation of 5-hydroxyindoles under such mild conditions is explained in terms of a non-redox mechanism.
