ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate

Base Information

Chemical Name:ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate
CAS No.:1020575-25-0
Molecular Formula:C₃₂H₂₈Cl₂N₂O₄
Molecular Weight:575.491
Hs Code.:

Synonyms:ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate

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Chemical Property of ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate

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Technology Process of ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate

There total 5 articles about ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 700835-81-0
4-(chloromethyl)-3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole

: 1020575-19-2
ethyl 6-(4-hydroxyphenyl)-3-methyl-2-quinolinecarboxylate

: 1020575-25-0
ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 15933-07-0
Ethyl 2-oxobutanoate

: 1020575-25-0
ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tin(ll) chloride; zinc(II) chloride / diethyl ether; ethanol / 3 h / 70 °C / Molecular sieve; Inert atmosphere

2: potassium phosphate; palladium diacetate; triphenylphosphine / 1,4-dioxane; water / 17 h / 60 °C

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium phosphate; palladium diacetate; caesium carbonate; triphenylphosphine; tin(ll) chloride; zinc(II) chloride; In 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.089

Reference yield:

: 1020575-13-6
ethyl 6-bromo-3-methyl-2-quinolinecarboxylate

: 1020575-25-0
ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-3-methyl-2-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; palladium diacetate; triphenylphosphine / 1,4-dioxane; water / 17 h / 60 °C

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium phosphate; palladium diacetate; caesium carbonate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.089