15933-07-0Relevant articles and documents
A New Synthesis of α-Keto Esters and Acids
Nimitz, Jonathan S.,Mosher, Harry S.
, p. 211 - 213 (1981)
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Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and evaluation of their influence on melanin synthesis in murine B16 cells
Nie, Li Fei,Huang, Guozheng,Bozorov, Khurshed,Zhao, Jiangyu,Niu, Chao,Sagdullaev, Shamansur S.,Aisa, Haji A.
, p. 43 - 50 (2018)
A diversity-oriented synthesis of amide-containing thieno[2,3-d]pyrimidin-4(3H)-ones is reported. All compounds were tested for their influence on melanin synthesis in murine B16 cells. The azepine fragment in thieno[2,3-d]pyrimidin-4(3H)-one skeleton significantly increases the melanin content.
Tominaga et al.
, p. 830 (1966)
Synthesizing method for dimethyl-3-hydroxy-2,5-dihydrofuran-2-one spice
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Paragraph 0042-0052, (2019/10/23)
The invention discloses a synthesizing method for dimethyl-3-hydroxy-2,5-dihydrofuran-2-one spice, and relates to the technical field of specie synthesis. According to the synthesizing method, the dimethyl-3-hydroxy-2,5-dihydrofuran-2-one is obtained by taking diethyl oxalate as a starting material, preparing 2-oxo-ethyl butyrate through a Grignard reaction in the absence of water and under the protection of nitrogen; cyclizing a required carbon skeleton under the action of potassium carbonate and acetaldehyde to obtain the dimethyl-3-hydroxy-2,5-dihydrofuran-2-one. A reaction solvent and an extracting agent can be used after being recycled; the process flow is reduced; the reaction yield is relatively high.
Diastereo- and Enantioselective Synthesis of Fluorine Motifs with Two Contiguous Stereogenic Centers
Ponra, Sudipta,Rabten, Wangchuk,Yang, Jianping,Wu, Haibo,Kerdphon, Sutthichat,Andersson, Pher G.
supporting information, p. 13878 - 13883 (2018/10/24)
The synthesis of chiral fluorine containing motifs, in particular, chiral fluorine molecules with two contiguous stereogenic centers, has attracted much interest in research due to the limited number of methods available for their preparation. Herein, we report an atom-economical and highly stereoselective synthesis of chiral fluorine molecules with two contiguous stereogenic centers via azabicyclo iridium-oxazoline-phosphine-catalyzed hydrogenation of readily available vinyl fluorides. Various aromatic, aliphatic, and heterocyclic systems with a variety of functional groups were found to be compatible with the reaction and provide the highly desirable product as single diastereomers with excellent enantioselectivities.
