2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

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Chemical Name:2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide
CAS No.:1268634-85-0
Molecular Formula:C₂₃H₁₉ClF₆N₈O₃
Molecular Weight:604.899
Hs Code.:

2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

Synonyms:2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

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Chemical Property of 2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

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Technology Process of 2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

There total 10 articles about 2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1268635-47-7
2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-cyano-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

: 1268634-85-0
2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; Reflux;

Reference yield:

: 1245940-76-4
(2R)-2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

: 1268634-85-0
2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 20 °C

2: di(n-butyl)tin oxide; trimethylsilylazide / toluene / Reflux

With pyridine; trimethylsilylazide; di(n-butyl)tin oxide; trifluoroacetic anhydride; In tetrahydrofuran; toluene;

Reference yield:

: 1245940-77-5
(2R)-2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanoic acid

: 1268634-85-0
2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(1R)-1-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

1.2: 0.33 h / 20 °C

2.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 20 °C

3.1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / Reflux

With pyridine; trimethylsilylazide; di(n-butyl)tin oxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic anhydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;