ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate

Base Information

• Chemical Name: ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate
• CAS No.: 370565-61-0
• Molecular Formula: C₁₈H₁₈ClN₃O₄S
• Molecular Weight: 407.878
• Mol file: 370565-61-0.mol

Synonyms:ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate

Chemical Property of ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate

There total 1 articles about ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

diazoacetic acid ethyl ester (623-73-4) + N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide (357417-22-2) → ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate (370565-61-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 8h;

DOI:10.1021/jo0259818

Reference yield: 83.0%

ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate (370565-61-0) → (Z)-3-(4-Chloro-phenyl)-3-(toluene-4-sulfonylamino)-acrylic acid ethyl ester + (E)-ethyl 2-(4-chlorophenyl)-3-(N-tosyl)amino-2-propenoate + (Z)-2-(4-Chloro-phenyl)-3-(toluene-4-sulfonylamino)-acrylic acid ethyl ester

Guidance literature:

With dirhodium tetraacetate; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1021/ol016324p

Reference yield: 83.0%

ethyl 2-diazo-3-(N-tosyl)amino-3-(p-chlorophenyl)propanoate (370565-61-0) → (E)-ethyl 2-(4-chlorophenyl)-3-(N-tosyl)amino-2-propenoate

Guidance literature:

With dirhodium tetraacetate; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1021/ol016324p

upstream raw materials:

diazoacetic acid ethyl ester

N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide