ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate

Base Information

Chemical Name:ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate
CAS No.:1374138-46-1
Molecular Formula:C₃₄H₄₂F₂N₄O₇S
Molecular Weight:688.793
Hs Code.:

Synonyms:ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate

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Chemical Property of ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate

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Technology Process of ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate

There total 12 articles about ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374138-45-0
ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-4,4-difluoro-N2-[(4-nitrophenyl)sulfonyl]-N2-propan-2-yl-L-lysinate

: 1374138-46-1
ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; under 760.051 Torr;

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1374138-46-1
ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / dmap / acetonitrile / 20 °C

2.1: dmap / acetonitrile / 48 h / 20 °C

3.1: diisobutylaluminium hydride / toluene; diethyl ether / 0.75 h / -70 °C

3.2: 1.5 h / 20 °C

4.1: N-fluorobis(benzenesulfon)imide; rac-Pro-OH / isopropyl alcohol; tetrahydrofuran / 24 h / 20 °C

4.2: 0 - 20 °C

4.3: 3 h / 0 - 20 °C

5.1: water; sodium tetrahydroborate / tetrahydrofuran / 4 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 h / 1810.07 Torr

7.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

8.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 2 h / 0 - 20 °C

9.1: pyridine / dmap / 85 °C

10.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

11.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 760.05 Torr

With pyridine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; water; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; methoxybenzene; N-fluorobis(benzenesulfon)imide; triethylamine; triphenylphosphine; trifluoroacetic acid; rac-Pro-OH; dmap; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1374138-46-1
ethyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-[(4-aminophenyl)sulfonyl]-4,4-difluoro-N2-propan-2-yl-L-lysinate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dmap / 85 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 760.05 Torr

With pyridine; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate;