2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide

Base Information

Chemical Name:2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide
CAS No.:1427214-84-3
Molecular Formula:C₁₉H₁₄ClF₃N₂O₅S
Molecular Weight:474.845
Hs Code.:

Synonyms:2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide

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Technology Process of 2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide

There total 5 articles about 2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 421-85-2
Trifluoromethanesulfonamide

: 59925-16-5
2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)acetyl chloride

: 1427214-84-3
2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide

Guidance literature:: With pyridine; In 1,2-dichloro-ethane; at 25 ℃; Inert atmosphere;
DOI:10.1021/jm3017656

Reference yield:

: 22781-96-0
indomethacin

: 1427214-84-3
2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

2: pyridine / 1,2-dichloro-ethane / 25 °C / Inert atmosphere

With pyridine; oxalyl dichloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm3017656

Reference yield:

: 23304-48-5
(5-methoxy-1H-indol-3-yl)acetic acid methyl ester

: 1427214-84-3
2-(1-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl)-N-((trifluoromethyl)sulfonyl) acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: trimethyl-tin hydroxide / 1,2-dichloro-ethane / 0.5 h / 130 °C / Microwave irradiation

3.1: oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

4.1: pyridine / 1,2-dichloro-ethane / 0.4 h / 20 °C

With pyridine; oxalyl dichloride; sodium hydride; trimethyl-tin hydroxide; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;