5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate

Base Information

Chemical Name:5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate
CAS No.:1372854-81-3
Molecular Formula:C₂₂H₃₂N₃O₁₈P₃
Molecular Weight:719.427
Hs Code.:

Synonyms:5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate

Suppliers and Price of 5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate

There total 9 articles about 5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372854-80-2
5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxyuridine

: 1372854-81-3
5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate / 1 h / 0 °C / Inert atmosphere

2.1: tributyl-amine; bis(tri-n-butylammonium) pyrophosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 1 h / 20 °C / pH 7.5 / Inert atmosphere; aq. buffer

With tributyl-amine; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; bis(tri-n-butylammonium) pyrophosphate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516

Reference yield:

: C₂₄H₃₄N₃O₁₂P

: 1372854-81-3
5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate

Guidance literature:: C₂₄H₃₄N₃O₁₂P; With tributyl-amine; bis(tri-n-butylammonium) pyrophosphate; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

In N,N-dimethyl-formamide; at 20 ℃; for 1h; pH=7.5; Inert atmosphere; aq. buffer;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-34-6
(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1372854-81-3
5-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2’-deoxyuridine-5’-triphosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / dichloromethane / 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 1 h / Reflux

3.1: 0.75 h / 110 °C / Inert atmosphere

4.1: ammonium fluoride / methanol / 12 h / 50 °C / Inert atmosphere

5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate / 1 h / 0 °C / Inert atmosphere

6.1: tributyl-amine; bis(tri-n-butylammonium) pyrophosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

6.2: 1 h / 20 °C / pH 7.5 / Inert atmosphere; aq. buffer

With dmap; ammonium fluoride; tributyl-amine; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; bis(tri-n-butylammonium) pyrophosphate; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516