(R_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate

Base Information

• Chemical Name: (R_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate
• CAS No.: 90865-75-1
• Molecular Formula: C₄₄H₄₉N₄O₁₄P
• Molecular Weight: 888.865

Synonyms:(R_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate

Chemical Property of (R_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate

Chemical Property:

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Technology Process of (R_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate

There total 12 articles about (R_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5'-O-DMT thymidylyl 3'-O-acetylthymidine (3',5')-methanephosphonothioate (252931-78-5) → (RP)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate (90865-75-1)

Guidance literature:

With Oxone; pH=6 - 7;

Reference yield: 92.0%

3'-O-acetylthymidine (21090-30-2) + (Rp)-5'-O-DMT-thymidine-3'-O-(Se-methyl methanephosphonoselenolate) (160971-73-3) → (RP)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate (90865-75-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In pyridine; Ambient temperature;

DOI:10.1021/jo00099a001

Reference yield: 92.0%

3'-O-acetylthymidine (21090-30-2) + (S)-Methyl-phosphonothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester (129395-81-9) → (RP)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate (90865-75-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; for 2h;

DOI:10.1021/jo980225g

upstream raw materials:

3'-O-acetylthymidine

(Rp)-5'-O-DMT-thymidine-3'-O-(Se-methyl methanephosphonoselenolate)

(S)-Methyl-phosphonothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-methyl ester

(S_P)-5'-O-DMT-thymidine 3'-O-(S-phenyl methanephosphonothioate)

Downstream raw materials:

C₄₂H₄₇N₄O₁₃P

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