(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide

Base Information

Chemical Name:(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide
CAS No.:313673-95-9
Molecular Formula:C₁₇H₁₄Cl₂N₂O₃
Molecular Weight:365.216
Hs Code.:

Synonyms:(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide

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Chemical Property of (7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide

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Technology Process of (7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide

There total 3 articles about (7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 7073-36-1
2-chloro-4-nitrobenzoyl chloride

: 313673-94-8
7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepine

: 313673-95-9
(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide

Guidance literature:: With pyridine; In dichloromethane; for 1h;
DOI:10.1021/jm000108p

Reference yield:

: 193686-76-9
7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 313673-95-9
(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / hydrazine monohydrate; KOH / bis-(2-hydroxy-ethyl) ether / 6 h / Heating

2: 100 percent / Mg; methanol / 4 h

3: 77 percent / pyridine / CH₂Cl₂ / 1 h

With pyridine; methanol; potassium hydroxide; hydrazine hydrate; magnesium; In dichloromethane; diethylene glycol; 1: Wolff-Kishner reduction;
DOI:10.1021/jm000108p

Reference yield:

: 313673-93-7
7-chloro-1-toluenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine

: 313673-95-9
(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Mg; methanol / 4 h

2: 77 percent / pyridine / CH₂Cl₂ / 1 h

With pyridine; methanol; magnesium; In dichloromethane;
DOI:10.1021/jm000108p