(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide

Base Information

Chemical Name:(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide
CAS No.:313673-97-1
Molecular Formula:C₁₇H₁₆Cl₂N₂O
Molecular Weight:335.233
Hs Code.:

Synonyms:(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide

Chemical Property:

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Technology Process of (7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide

There total 5 articles about (7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 313673-95-9
(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-2-chloro-4-nitrobenzamide

: 313673-97-1
(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide

Guidance literature:: With tin(ll) chloride; In ethanol; for 3h; Heating;
DOI:10.1021/jm000108p

Reference yield:

: 7073-36-1
2-chloro-4-nitrobenzoyl chloride

: 313673-97-1
(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / pyridine / CH₂Cl₂ / 1 h

2: 84 percent / SnCl₂*2H₂O / ethanol / 3 h / Heating

With pyridine; tin(ll) chloride; In ethanol; dichloromethane;
DOI:10.1021/jm000108p

Reference yield:

: 193686-76-9
7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 313673-97-1
(7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)-4-amino-2-chlorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / hydrazine monohydrate; KOH / bis-(2-hydroxy-ethyl) ether / 6 h / Heating

2: 100 percent / Mg; methanol / 4 h

3: 77 percent / pyridine / CH₂Cl₂ / 1 h

4: 84 percent / SnCl₂*2H₂O / ethanol / 3 h / Heating

With pyridine; methanol; potassium hydroxide; hydrazine hydrate; magnesium; tin(ll) chloride; In ethanol; dichloromethane; diethylene glycol; 1: Wolff-Kishner reduction;
DOI:10.1021/jm000108p