POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE

Base Information

• Chemical Name: POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE
• CAS No.: 850623-45-9
• Molecular Formula: C14H12 B F3 N O2 . K
• Molecular Weight: 333.159
• Mol file: 850623-45-9.mol

Synonyms:Potassium[4-[(benzyloxycarbonyl)amino]phenyl]trifluoroborate

Chemical Property of POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE

Chemical Property:

• Melting Point: 250-266℃
• PSA: 38.33000
• LogP: 3.56270
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Potassium(4-CBZ-aminophenyl)trifluoroborate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE

There total 2 articles about POTASSIUM (4-CBZ-AMINOPHENYL)TRIFLUOROBORATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H18BNO4 → 4-(benzyloxycarbonylamino)-phenyl trifluoroborate (850623-45-9)

Guidance literature:

With potassium hydrogen bifluoride; In water; at -10 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201000852

Reference yield:

C14H12BrMgNO2 → 4-(benzyloxycarbonylamino)-phenyl trifluoroborate (850623-45-9)

Guidance literature:

C₁₄H₁₂BrMgNO₂; With Trimethyl borate; at -30 ℃;

With potassium hydrogenfluoride; water;

DOI:10.1016/j.tet.2009.11.027

Reference yield: 85.0%

4-(benzyloxycarbonylamino)-phenyl trifluoroborate (850623-45-9) + 2-(4-chloro-1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ol → benzyl (4-(2-(2-hydroxypropan-2-yl)-1H-pyrrolo[3,2-c]pyridin-4-yl)phenyl)carbamate

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In water; acetonitrile; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.01.040

Downstream raw materials:

C₂₆H₂₄N₂O₃

C₂₀H₁₉NO₃

benzyl 4-(2,2,6-trimethyl-4-oxo-4H-1,3-dioxin-5-yl)phenylcarbamate

Refernces

• 1、 Stefani, Helio A.,Amaral, Monica F. Z. J.,Reyes-Rangel, Gloria,Vargas-Caporali, Jorge,Juaristi, Eusebio. "Functionalization of (2S)-Isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4- ones by a Suzuki-Miyaura Cross-Coupling Reaction Using Aryltrifluoroborate Salts: Convenient Enantioselective Preparation of α-Substituted β-Amino Acids". experimental part. p. 6393 - 6403. Retrieved 2011/02/21.