5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE

Base Information

• Chemical Name: 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
• CAS No.: 18672-03-2
• Molecular Formula: C7H5Cl2N3
• Molecular Weight: 202.043
• Hs Code.: 2933990090
• Mol file: 18672-03-2.mol

Synonyms:Benzimidazole,2-amino-5,6-dichloro- (8CI);2-Amino-5,6-dichloro-1H-benzimidazole;2-Amino-5,6-dichlorobenzimidazole;5,6-Dichloro-1H-benzimidazol-2-amine;5,6-Dichloro-2-aminobenzimidazole;

Chemical Property of 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE

Chemical Property:

• Vapor Pressure: 8.78E-08mmHg at 25°C
• Melting Point: 244-246℃
• Refractive Index: 1.775
• Boiling Point: 435.4 °C at 760 mmHg
• PKA: 8.47±0.10(Predicted)
• Flash Point: 217.1 °C
• PSA: 54.70000
• Density: 1.665 g/cm³
• LogP: 3.03310
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5,6-dichloro-1H-benzo[d]imidazol-2-amine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-5,6-dichlorobenzimidazole is used as pharmaceutical intermediate.

Technology Process of 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE

There total 5 articles about 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2-amino-5,6-dichlorobenzimidazole (18672-03-2)

Guidance literature:

In ethanol; at 50 ℃;

Reference yield: 98.0%

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) + bromocyane (506-68-3) → 2-amino-5,6-dichlorobenzimidazole (18672-03-2)

Guidance literature:

In methanol; water; acetonitrile; Ambient temperature;

DOI:10.1021/jm00020a025

Reference yield: 89.0%

1H-benzimidazol-2-amine (934-32-7) + conc. NH4 OH → 2-amino-5,6-dichlorobenzimidazole (18672-03-2)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; In water;

upstream raw materials:

4,5-Dichloro-1,2-phenylenediamine

bromocyane

4,5-dichloro-2-nitroaniline

pyrographite

Downstream raw materials:

2-bromo-5,6-dichloro-1H-1,3-benzodiazole

2,5,6-trichloro-1H-benzo[d]imidazole