ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt

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Chemical Name:ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt
CAS No.:1411034-28-0
Molecular Formula:C₂H₂O₄*C₂₉H₂₉N₇O₄
Molecular Weight:629.629
Hs Code.:

Synonyms:ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt

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Chemical Property of ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt

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Technology Process of ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt

There total 3 articles about ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: N-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]glycine

: 144-62-7,97993-78-7
oxalic acid

: 212322-56-0
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

: 1411034-28-0
ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt

Guidance literature:: N-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]glycine; ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 - 50 ℃; for 2h;

oxalic acid; In ethyl acetate;

Reference yield:

: 10185-68-9
4-(5-methyl-1,2,4-oxadiazol-3-yl)-aniline

: 1411034-28-0
ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / potassium iodide / toluene / 24 h / boiling

2.1: sodium hydroxide / 20 °C

2.2: pH 5

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 2 h / 20 - 50 °C

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; sodium hydroxide; potassium iodide; In ethyl acetate; toluene;

Reference yield:

: 253796-85-9
ethyl N-[4-(5-methyl-1,2,4-oxadiazole-3-yl)phenyl]glycinate

: 1411034-28-0
ethyl N-{[1-methyl-2-({[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]amino}methyl)-1H-benzimidazol-5-yl]carbonyl}-N-(pyridin-2-yl)-β-alaninate oxalate salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 20 °C

1.2: pH 5

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 2 h / 20 - 50 °C

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; sodium hydroxide; In ethyl acetate;