N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide

Base Information

Chemical Name:N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide
CAS No.:1227845-38-6
Molecular Formula:C₁₉H₂₀F₂N₂O₄
Molecular Weight:378.376
Hs Code.:

Synonyms:N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide

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Technology Process of N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide

There total 10 articles about N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1227845-64-8
N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide

: 1227845-38-6
N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 30 ℃; under 760.051 Torr;

Reference yield:

: 38998-17-3
2,3-dimethyl-4-methoxybenzaldehyde

: 1227845-38-6
N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium chlorite; sodium dihydrogenphosphate / dimethyl sulfoxide / 1 h / 40 °C

2.1: sec.-butyllithium / tetrahydrofuran / 0.5 h / -78 - -65 °C / Inert atmosphere

2.2: -78 °C

2.3: 0.5 h / Cooling with ice

3.1: boron tribromide / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: Cooling with ice

4.1: potassium carbonate / acetone / 18 h / Reflux

4.2: 3 h / Reflux

4.3: 0.5 h / pH 1

5.1: sulfuric acid / 18 h / 67 °C

6.1: hydrazine hydrate / isopropyl alcohol; iso-butanol / 18 h / Reflux

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

8.1: hydrogen / palladium 10% on activated carbon / methanol / 30 °C / 760.05 Torr

With sodium chlorite; sodium dihydrogenphosphate; sulfuric acid; hydrogen; sec.-butyllithium; boron tribromide; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetone; iso-butanol;

Reference yield:

: 1181770-76-2
2-ethyl-4-methoxy-3-methylbenzoic acid

: 1227845-38-6
N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-2-ethyl-4-hydroxy-3-methyl-benzohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: Cooling with ice

2.1: potassium carbonate / acetone / 18 h / Reflux

2.2: 3 h / Reflux

2.3: 0.5 h / pH 1

3.1: sulfuric acid / 18 h / 67 °C

4.1: hydrazine hydrate / isopropyl alcohol; iso-butanol / 18 h / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / methanol / 30 °C / 760.05 Torr

With sulfuric acid; hydrogen; boron tribromide; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone; iso-butanol;