N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide

Base Information

Chemical Name:N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide
CAS No.:1227845-64-8
Molecular Formula:C₂₆H₂₆F₂N₂O₄
Molecular Weight:468.5
Hs Code.:

Synonyms:N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide

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Chemical Property of N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide

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Technology Process of N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide

There total 9 articles about N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261762-35-0
5-bromo-1,2-difluoro-3-methoxy-benzene

: 1227845-64-8
N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 48 h / Inert atmosphere; Reflux

2.1: ozone; acetic acid / ethyl acetate; water / 0.5 h / 0 - 50 °C

2.2: 2 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; ozone; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 38998-17-3
2,3-dimethyl-4-methoxybenzaldehyde

: 1227845-64-8
N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium chlorite; sodium dihydrogenphosphate / dimethyl sulfoxide / 1 h / 40 °C

2.1: sec.-butyllithium / tetrahydrofuran / 0.5 h / -78 - -65 °C / Inert atmosphere

2.2: -78 °C

2.3: 0.5 h / Cooling with ice

3.1: boron tribromide / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: Cooling with ice

4.1: potassium carbonate / acetone / 18 h / Reflux

4.2: 3 h / Reflux

4.3: 0.5 h / pH 1

5.1: sulfuric acid / 18 h / 67 °C

6.1: hydrazine hydrate / isopropyl alcohol; iso-butanol / 18 h / Reflux

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; sulfuric acid; sec.-butyllithium; boron tribromide; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetone; iso-butanol;

Reference yield:

: 1227845-51-3
2-ethyl-4-hydroxy-3-methylbenzoic acid

: 1227845-64-8
N'-[2-(3,4-difluoro-5-methoxyphenyl)acetyl]-4-benzyloxy-2-ethyl-3-methylbenzohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 18 h / Reflux

1.2: 3 h / Reflux

1.3: 0.5 h / pH 1

2.1: sulfuric acid / 18 h / 67 °C

3.1: hydrazine hydrate / isopropyl alcohol; iso-butanol / 18 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With sulfuric acid; potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; isopropyl alcohol; acetone; iso-butanol;