Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester

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Chemical Name:Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester
CAS No.:246538-22-7
Molecular Formula:C₄₈H₄₉N₃O₁₁S
Molecular Weight:875.997
Hs Code.:

Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester

Synonyms:Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester

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Chemical Property of Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester

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Technology Process of Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester

There total 7 articles about Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52450-18-7
3'-amino-3'-deoxythymidine

: 246538-22-7
Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / Na₂CO₃ / 1 h / 20 °C

2: 79 percent / DMSO; DCC; TFA / pyridine / 4 h / 20 °C

3: Zn / tetrahydrofuran / 20 h / 40 °C

4: AgNO₃; pyridine / 24 h / 50 °C

5: LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

6: pyridine / 4 h / 20 °C

With pyridine; lithium aluminium tetrahydride; sodium carbonate; silver nitrate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In tetrahydrofuran; pyridine; 1: Acylation / 2: Oxidation / 3: Condensation / 4: Etherification / 5: Reduction / 6: Tosylation;
DOI:10.1016/S0040-4039(99)01205-8

Reference yield:

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 246538-22-7
Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / H₂ / 10 percent Pd/C / 6 h / 20 °C

2: 87 percent / Na₂CO₃ / 1 h / 20 °C

3: 79 percent / DMSO; DCC; TFA / pyridine / 4 h / 20 °C

4: Zn / tetrahydrofuran / 20 h / 40 °C

5: AgNO₃; pyridine / 24 h / 50 °C

6: LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

7: pyridine / 4 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium carbonate; silver nitrate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; pyridine; 1: Reduction / 2: Acylation / 3: Oxidation / 4: Condensation / 5: Etherification / 6: Reduction / 7: Tosylation;
DOI:10.1016/S0040-4039(99)01205-8

Reference yield:

: 246538-34-1
[(2S,3S,5R)-2-Formyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-carbamic acid benzyl ester

: 246538-22-7
Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Zn / tetrahydrofuran / 20 h / 40 °C

2: AgNO₃; pyridine / 24 h / 50 °C

3: LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

4: pyridine / 4 h / 20 °C

With pyridine; lithium aluminium tetrahydride; silver nitrate; zinc; In tetrahydrofuran; 1: Condensation / 2: Etherification / 3: Reduction / 4: Tosylation;
DOI:10.1016/S0040-4039(99)01205-8