1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate
CAS No.:1262786-61-7
Molecular Formula:C₂₇H₄₁NO₅SSi
Molecular Weight:519.778
Hs Code.:

Synonyms:1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate

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Chemical Property of 1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate

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Technology Process of 1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate

There total 7 articles about 1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1262786-58-2
N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)benzenesulfonamide

: 1262786-61-7
1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate

Guidance literature:: N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide;

di-tert-butyl dicarbonate; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 1262786-57-1
N-(4-hydroxy-2-phenylbutyl)benzenesulfonamide

: 1262786-61-7
1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole; dmap / dichloromethane / 0.5 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide

2.2: 1 h / 20 °C

With 1H-imidazole; dmap; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 1262786-56-0
ethyl 3-phenyl-4-[(phenylsulfonyl)amino]butanoate

: 1262786-61-7
1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran / 2 h / 65 °C

2.1: 1H-imidazole; dmap / dichloromethane / 0.5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide

3.2: 1 h / 20 °C

With 1H-imidazole; dmap; lithium borohydride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.030