1262786-58-2

Upstream product

• 1262786-56-0 ethyl 3-phenyl-4-[(phenylsulfonyl)amino]butanoate 
• 5292-53-5 diethyl benzalmalonate 
• 14025-83-3 3-cyano-3-phenylpropanoic acid ethyl ester 
• 1262786-57-1 N-(4-hydroxy-2-phenylbutyl)benzenesulfonamide 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1283568-95-5 C₃₁H₃₆N₄O₂S 
• 1262786-33-3 N-{4-[(1R,5S)-3-(2-methyl-3H-imidazo[4,5-c]pyridin-3-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide 
• 1262786-35-5 N-{4-[(1R,5S)-3-(5-acetyl-2-methyl-4,5,6,7-tetrahvdro-3H-imidazo[4.5-c]pyridin-3-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide 
• 1282658-00-7 C₃₂H₃₈N₄O₂S 
• 1282658-01-8 C₂₇H₃₇N₅O₂S 
• 1282658-02-9 C₃₀H₃₅N₅O₂S 
• 1282658-03-0 C₃₃H₄₀N₄O₂S 
• 1282658-05-2 C₂₉H₃₄N₄O₂S 
• 1282658-07-4 C₃₇H₄₁N₃O₆S₂ 
• 1262786-63-9 C₂₁H₂₅NO₅S 
• 1262786-62-8 1,1-dimethylethyl (4-hydroxy-2-phenylbutyl)(phenylsulfonyl)carbamate 
• 1262786-61-7 1,1-dimethylethyl (4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)(phenylsulfonyl)carbamate 
• 1262786-59-3 N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide 
• 220394-85-4 (R,S)-N-(2-Phenyl-4-oxobut-1-yl)-N-methylbenzene-sulfonamide 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS

The present invention relates to compounds of Formula (I) and (Ia) useful in the treatment of CCR5-related diseases and disorders, for example, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficien

Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1

We describe the synthesis and potency of a novel series of N-substituted 2-phenyl- and 2-methyl-2-phenyl-1,4-diaminobutane- based CCR5 antagonists. Compounds 7a and 12f were found to be potent in anti-HIV assays and bioavailable in the low-dose rat PK model.