(2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine

Base Information

Chemical Name:(2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine
CAS No.:960208-73-5
Molecular Formula:C₁₇H₂₁F₃N₂O₃
Molecular Weight:358.361
Hs Code.:

Synonyms:(2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine

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Chemical Property of (2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine

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Technology Process of (2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine

There total 1 articles about (2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 198649-68-2
2-(trifluoromethoxy)benzyl bromide

: 960208-73-5
(2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine

Guidance literature:: (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

2-(trifluoromethoxy)benzyl bromide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.5h;

Reference yield:

: 960208-73-5
(2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine

: 76-05-1
trifluoroacetic acid

: C₁₃H₁₁F₆NO₄

Guidance literature:: In dichloromethane; acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 960208-73-5
(2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine

: 959845-31-9
N-Boc-D-2-OCF₃-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane; acetonitrile / 1 h / 20 °C

2: potassium carbonate / tetrahydrofuran / 2 h / 20 °C

3: lithium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C

With lithium hydroxide; water; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;