198649-68-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(Trifluoromethoxy)benzyl bromide is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its reactivity allows for the creation of new molecules with potential therapeutic applications, contributing to the advancement of drug discovery and design.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Trifluoromethoxy)benzyl bromide is utilized as a key component in the synthesis of pesticides and other agrochemical products. Its role in creating effective and innovative compounds aids in enhancing crop protection and management strategies.
Used as a Versatile Reagent:
2-(Trifluoromethoxy)benzyl bromide is employed as a versatile reagent in various chemical reactions. Its strong reactivity enables the formation of new chemical entities, broadening the scope of chemical research and development across different industries.

InChI:InChI=1/C8H6BrF3O/c9-5-6-3-1-2-4-7(6)13-8(10,11)12/h1-4H,5H2

Upstream product

• 94651-33-9 2-(trifluoromethoxy)benzaldehyde 
• 175278-07-6 2-trifluoromethoxy-benzyl alcohol 

Downstream Products

• 960208-73-5 (2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2-trifluoromethoxy-benzyl)-2,5-dihydro-pyrazine 
• 800407-81-2 (S,R)-1-(4-benzyl-morpholin-2-yl)-1-phenyl-2-(2-trifluorometoxy-phenyl)-ethanol 
• 919112-65-5 C₂₂H₃₃F₃N₂O₄S 
• 1353753-55-5 (6S)-2-nitro-6-{[2-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 
• 1415663-96-5 C₂₃H₁₇F₃N₆OS 
• 1421597-03-6 C₂₁H₂₂F₃N₃O₄ 
• 1455006-30-0 benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-(2-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate 
• 959845-31-9 N-Boc-D-2-OCF₃-phenylalanine 
• 950509-80-5 [(R)-1-((R)-1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-ylcarbamoyl)-2-(2-trifluoromethoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 960208-74-6 (R)-2-tert-butoxycarbonylamino-3-(2-trifluoromethoxy-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation

The selective functionalization of C-H bonds at the arene para position is highly challenging using transition metal catalysis. Iridium-catalyzed borylation has emerged as a leading technique for arene functionalization, but there are only a handful of strategies for para-selective borylation, which operate on specific substrate classes and use bespoke ligands or catalysts. We describe a remarkably general protocol which results in para-selectivity on some of the most common arene building blocks (anilines, benzylamines, phenols, benzyl alcohols) and uses standard borylation ligands. Our strategy hinges upon the facile conversion of the substrates into sulfate or sulfamate salts, wherein the anionic arene component is paired with a tetrabutylammonium cation. We hypothesize that the bulk of this cation disfavors meta-C-H borylation, thereby promoting the challenging para-selective reaction.

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein we describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure–activity studies reveal a critical linker region in these molecules as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) analysis of RORγ–ligand complexes help rationalize the observed results.

Tocolytic oxytocin receptor antagonists

This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

PIPERAZINE OXYTOCIN RECEPTOR ANTAGONISTS

This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.