4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt

Base Information

Chemical Name:4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt
CAS No.:1419186-29-0
Molecular Formula:C₁₀H₁₅N*C₃₁H₃₀Cl₂FN₃O₅
Molecular Weight:763.737
Hs Code.:

4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt

Synonyms:4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt

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Chemical Property of 4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt

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Technology Process of 4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt

There total 13 articles about 4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: rac-4-((2’S,3’R,4’S,5’R)-6-chloro-4’-(3-chloro-2-fluorophenyl)-2’-neopentyl-2-oxospiro[indoline-3,3’-pyrrolidine]-5’-carboxamido)-3-methoxybenzoic acid

: 19342-01-9
(S)-N,N-dimethyl-1-phenylethylamine

: 1419186-29-0
4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt

Guidance literature:: In ethyl acetate; at 60 ℃; for 2h;
DOI:10.1021/op3003213

Reference yield:

: 56341-37-8
6-chloro-2-oxindole

: 1419186-29-0
4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / methanol / 20 °C / Reflux

2.1: silver(I) acetate; (6,6’-dimethoxy-[1,1 ‘-biphenyl]-2,2’-diyl)bis(bis(3 ,5-dimethyl-phenyl)phosphine); triethylamine / 2-methyltetrahydrofuran / 28 h / 40 °C

2.2: Reflux

3.1: sodium hydroxide / tetrahydrofuran; water / 4 h / 65 °C

4.1: ethyl acetate / 4 h / 60 °C

With piperidine; (6,6’-dimethoxy-[1,1 ‘-biphenyl]-2,2’-diyl)bis(bis(3 ,5-dimethyl-phenyl)phosphine); silver(I) acetate; triethylamine; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1021/op3003213

Reference yield:

: 85070-48-0
2-fluoro-3-chlorobenzaldehyde

: 1419186-29-0
4-{[(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carbonyl]amino}-3-methoxybenzoic acid dimethyl-((R)-1-phenylethyl)amine salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / methanol / 20 °C / Reflux

2.1: silver(I) acetate; (6,6’-dimethoxy-[1,1 ‘-biphenyl]-2,2’-diyl)bis(bis(3 ,5-dimethyl-phenyl)phosphine); triethylamine / 2-methyltetrahydrofuran / 28 h / 40 °C

2.2: Reflux

3.1: sodium hydroxide / tetrahydrofuran; water / 4 h / 65 °C

4.1: ethyl acetate / 4 h / 60 °C

With piperidine; (6,6’-dimethoxy-[1,1 ‘-biphenyl]-2,2’-diyl)bis(bis(3 ,5-dimethyl-phenyl)phosphine); silver(I) acetate; triethylamine; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1021/op3003213