2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione

Base Information

Chemical Name:2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione
CAS No.:1393844-08-0
Molecular Formula:C₁₉H₁₂F₃NO₃
Molecular Weight:359.304
Hs Code.:

Synonyms:2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione

Suppliers and Price of 2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione

There total 8 articles about 2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393844-12-6
2,2-dimethyl-7-((2-(trifluoromethyl)phenyl)ethynyl)-2H-pyrano[2,3-b]pyridin-4(3H)-one

: 1393844-08-0
2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione

Guidance literature:: With hydrogenchloride; isopentyl nitrite; In ethanol; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2017.03.068

Reference yield:

: 1393844-04-6
1-(6-chloro-2-methoxypyridin-3-yl)-3-methylbutane-1,3-diol

: 1393844-08-0
2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: acetic acid; hydrogen bromide / neat (no solvent) / 2 h / 80 °C

2.2: 255 / 5 h / 100 °C

3.1: hydrogenchloride / water; tetrahydrofuran; 1,4-dioxane / 5 h / 20 °C

3.2: 2 h / 100 °C

4.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

4.2: 12 h / Inert atmosphere

4.3: 4 h / 20 °C

5.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / dimethyl sulfoxide / 4 h / 100 °C

6.1: isopentyl nitrite; hydrogenchloride / ethanol / 6 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen bromide; acetic acid; triethylamine; pyridinium chlorochromate; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; 4.1: |Sonogashira Cross-Coupling / 4.2: |Sonogashira Cross-Coupling / 5.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2017.03.068

Reference yield:

: 65515-33-5
6-chloro-2-methoxypyridine-3-carboxylic acid

: 1393844-08-0
2,2-dimethyl-7-{[2-(trifluoromethyl)phenyl]ethynyl}-2H-pyrano[2,3-b]pyridine-3,4-dione

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran; acetonitrile / 3 h / 20 °C

1.2: 15 h / 0 - 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran / 4 h / 0 °C

3.1: tetrahydrofuran / 4 h / 0 °C

4.1: pyridinium chlorochromate / dichloromethane / 20 °C

5.1: acetic acid; hydrogen bromide / neat (no solvent) / 2 h / 80 °C

5.2: 255 / 5 h / 100 °C

6.1: hydrogenchloride / water; tetrahydrofuran; 1,4-dioxane / 5 h / 20 °C

6.2: 2 h / 100 °C

7.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

7.2: 12 h / Inert atmosphere

7.3: 4 h / 20 °C

8.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / dimethyl sulfoxide / 4 h / 100 °C

9.1: isopentyl nitrite; hydrogenchloride / ethanol / 6 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; hydrogen bromide; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; pyridinium chlorochromate; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 3.1: |Grignard Reaction / 7.1: |Sonogashira Cross-Coupling / 7.2: |Sonogashira Cross-Coupling / 8.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2017.03.068