4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile

Base Information

Chemical Name:4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile
CAS No.:1001398-15-7
Molecular Formula:C₂₁H₂₃N₃O₃S
Molecular Weight:397.498
Hs Code.:

Synonyms:4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile

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Chemical Property of 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile

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Technology Process of 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile

There total 1 articles about 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001398-03-3
1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride

: 506-68-3
bromocyane

: 1001398-15-7
4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile

Guidance literature:: 1-[4-(methylsulfonyl)phenyl]-4-(4-piperidinyloxy)-2,3-dihydro-1H-indole hydrochloride; bromocyane; With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20 ℃; for 18h;

With sodium carbonate; In dichloromethane; water; pH=~ 7;

Reference yield:

: 1001398-15-7
4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile

: 849833-56-3,35613-84-4,1202858-97-6
N-hydroxyisobutyramidine

: 1001398-17-9
4-({1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}oxy)-1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indole

Guidance literature:: 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarbonitrile; N-hydroxyisobutyramidine; With zinc(II) chloride; In diethyl ether; ethyl acetate; for 0.25h;

With hydrogenchloride; In ethanol; for 1h; Heating / reflux;