4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

Base Information

• Chemical Name: 4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester
• CAS No.: 740806-08-0
• Molecular Formula: C₁₅H₁₂F₆O₂
• Molecular Weight: 338.249
• Mol file: 740806-08-0.mol

Synonyms:4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

Chemical Property of 4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester

There total 2 articles about 4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

2-(3,5-bis(trifluoromethyl)phenyl)acetyl chloride (174083-39-7) + (carbethoxyethylidene)triphenylphosphorane (21382-82-1) → 4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester (740806-08-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo040139i

Reference yield:

3,5-bistrifluoromethylphenyl acetic acid (85068-33-3) → 4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester (740806-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: 23 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jo040139i

Reference yield: 58.0%

epoxybutene (930-22-3,62249-81-4) + 4-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester (740806-08-0) → 2-(3,5-bis(trifluoromethyl)phenylethynyl)-6-hydroxy-2-methyl-4-hexenoic acid ethyl ester

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 24h; under 258.574 Torr;

DOI:10.1021/jo040139i

upstream raw materials:

2-(3,5-bis(trifluoromethyl)phenyl)acetyl chloride

(carbethoxyethylidene)triphenylphosphorane

3,5-bistrifluoromethylphenyl acetic acid