N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide

Base Information

Chemical Name:N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide
CAS No.:1187214-20-5
Molecular Formula:C₂₉H₃₂FN₃O₅S
Molecular Weight:553.655
Hs Code.:

Synonyms:N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide

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Chemical Property of N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide

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Technology Process of N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide

There total 4 articles about N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1187214-19-2
N-(4-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide

: 1187214-20-5
N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide

Guidance literature:: With iron; ammonium chloride; In methanol; water; for 4h; Reflux;

Reference yield:

: 918643-33-1
7-(2-fluoro-4-nitrophenoxy)-2-iodothieno[3,2-b]pyridine

: 1187214-20-5
N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / Inert atmosphere; Reflux

2.1: acetic acid / dichloromethane / 1 h / 20 °C

2.2: 18 h / 20 °C

3.1: tetrahydrofuran / 24 h / 20 °C

4.1: iron; ammonium chloride / methanol; water / 4 h / Reflux

With iron; sodium carbonate; ammonium chloride; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 87199-17-5
4-formylphenylboronic acid,

: 1187214-20-5
N-(4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / Inert atmosphere; Reflux

2.1: acetic acid / dichloromethane / 1 h / 20 °C

2.2: 18 h / 20 °C

3.1: tetrahydrofuran / 24 h / 20 °C

4.1: iron; ammonium chloride / methanol; water / 4 h / Reflux

With iron; sodium carbonate; ammonium chloride; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;