(1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate)

Base Information

• Chemical Name: (1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate)
• CAS No.: 733800-70-9
• Molecular Formula: C₂₃H₂₀Cl₂O₃
• Molecular Weight: 415.316
• Mol file: 733800-70-9.mol

Synonyms:(1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate)

Chemical Property of (1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate)

There total 3 articles about (1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzaldehyde (104-88-1) + 1-phenyl-propan-1-one (93-55-0) → (1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate) (733800-70-9) + (1R,2R,3R)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 3-(4-chlorobenzoate)

Guidance literature:

With n-butyllithium; (R)-1,1'-Bi-2-naphthol; lanthanum(lll) triflate; In tetrahydrofuran; at 20 ℃; Title compound not separated from byproducts;

DOI:10.1021/ja047906f

Reference yield:

4-chlorobenzaldehyde (104-88-1) + 1-phenyl-propan-1-one (93-55-0) → (1S,2S,3S)-1-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 3-(4-chlorobenzoate) + (1R,2R,3R)-1-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 3-(4-chlorobenzoate) + (1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate) (733800-70-9) + (1R,2R,3R)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 3-(4-chlorobenzoate)

Guidance literature:

With ytterbium(III) triflate; (1R,2S)-N-monobutylnorephedrine; In 1,2-dimethoxyethane; at 20 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1039/b509505k

Reference yield:

4-chlorobenzaldehyde (104-88-1) + 1-phenyl-propan-1-one (93-55-0) → 3-(4-chloro-phenyl)-3-hydroxy-2-methyl-1-phenyl-propan-1-one (344258-89-5) + (1S,2S,3S)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 1-(4-chlorobenzoate) (733800-70-9) + (1R,2R,3R)-3-hydroxy-2-methyl-3-phenyl-1-(4-chlorophenyl)propyl 3-(4-chlorobenzoate)

Guidance literature:

With n-butyllithium; (R)-1,1'-Bi-2-naphthol; lanthanum(lll) triflate; In tetrahydrofuran; at 20 ℃; for 48h; Further Variations:; Reagents; Product distribution;

DOI:10.1002/chem.200500442

upstream raw materials:

4-chlorobenzaldehyde

1-phenyl-propan-1-one