2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Base Information

• Chemical Name: 2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride
• CAS No.: 1575612-10-0
• Molecular Formula: C₁₃H₁₂F₃N₃*ClH
• Molecular Weight: 303.715

Synonyms:2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Chemical Property of 2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

Chemical Property:

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Technology Process of 2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

There total 1 articles about 2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.3%

8-chloro-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine (1575612-32-6) → 2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride (1575612-10-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

DOI:10.1021/jm4016284

Reference yield: 35.5%

2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride (1575612-10-0) + 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole (124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2) → (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (1575607-85-0)

Guidance literature:

In acetonitrile; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm4016284

upstream raw materials:

8-chloro-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine

Downstream raw materials:

(2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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