(2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Base Information

• Chemical Name: (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• CAS No.: 1575607-85-0
• Molecular Formula: C₂₅H₂₃F₅N₆O
• Molecular Weight: 518.489

Synonyms:

Chemical Property of (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Technology Process of (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

There total 2 articles about (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.5%

2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride (1575612-10-0) + 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole (124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2) → (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (1575607-85-0)

Guidance literature:

In acetonitrile; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm4016284

Reference yield: 31.8%

→ (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-5,6-dihydroimidazo[1,2-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (1575607-85-0)

Guidance literature:

With lithium perchlorate; In acetonitrile; at 80 ℃; for 20h; Inert atmosphere;

upstream raw materials:

2-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

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