4-CHLORO-4'-MORPHOLINOMETHYL BENZOPHENONE

Base Information

• Chemical Name: 4-CHLORO-4'-MORPHOLINOMETHYL BENZOPHENONE
• CAS No.: 898769-96-5
• Molecular Formula: C₁₈H₁₈ClNO₂
• Molecular Weight: 315.799
• Mol file: 898769-96-5.mol

Synonyms:(4-chlorophenyl){4-[(morpholin-4-yl)methyl]phenyl}methanone

Chemical Property of 4-CHLORO-4'-MORPHOLINOMETHYL BENZOPHENONE

Chemical Property:

• Vapor Pressure: 2.42E-08mmHg at 25°C

Purity/Quality:

95% ^*data from raw suppliers

4-Chloro-4'-morpholinomethylbenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-CHLORO-4'-MORPHOLINOMETHYL BENZOPHENONE

There total 2 articles about 4-CHLORO-4'-MORPHOLINOMETHYL BENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

→ (4-chlorophenyl){4-[(morpholin-4-yl)methyl]phenyl}methanone (898769-96-5)

Guidance literature:

Reference yield: 81.0%

morpholine (110-91-8,99108-56-2) + 4-bromomethyl-4'-chlorobenzophenone (91457-11-3) → (4-chlorophenyl){4-[(morpholin-4-yl)methyl]phenyl}methanone (898769-96-5)

Guidance literature:

With triethylamine; In acetonitrile; at 0 ℃; for 1h;

DOI:10.1021/jm701247k

Reference yield: 89.5%

3-methoxyphenyl bromide (2398-37-0) + (4-chlorophenyl){4-[(morpholin-4-yl)methyl]phenyl}methanone (898769-96-5) → (±)-(4-chlorophenyl)(3-methoxyphenyl)(4-(morpholin-4-ylmethyl)phenyl)methanol (949934-28-5)

Guidance literature:

3-methoxyphenyl bromide; With magnesium; In tetrahydrofuran; Reflux;

(4-chlorophenyl){4-[(morpholin-4-yl)methyl]phenyl}methanone; In tetrahydrofuran; at 75 ℃; for 8h;

DOI:10.1016/j.bmcl.2015.09.007

upstream raw materials:

morpholine

4-bromomethyl-4'-chlorobenzophenone

Downstream raw materials:

(+/-)-(4-chlorophenyl)[4-(morpholinomethyl)phenyl]methanol

(±)-(4-chlorophenyl)(3-methoxyphenyl)(4-(morpholin-4-ylmethyl)phenyl)methanol

(±)-(benzo[d][1,3]dioxol-5-yl)(4-chlorophenyl)(4-(morpholin-4-ylmethyl)phenyl)methanol

(±)-(4-chlorophenyl)(4-methoxyphenyl)(4-(morpholin-4-ylmethyl)phenyl)methanol

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