91457-11-3

Upstream product

• 5395-79-9 4'-methyl-4-chlorobenzophenone 
• 94-36-0 dibenzoyl peroxide 
• 99-94-5 p-Toluic acid 
• 874-60-2 4-methyl-benzoyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 106-38-7 para-bromotoluene 

Downstream Products

• 184703-55-7 S-(4-(4-chlorobenzoyl)benzyl)thiouronium bromide 
• 183164-52-5 2-[4-(4-Chlorobenzoyl)benzyl]thio-3-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4(3H)-one 
• 183164-53-6 2-[4-(4-Chlorobenzoyl)benzyl]thio-1,7-dimethyl-6-oxopurine 
• 183164-63-8 9-[4-(4-Chlorobenzoyl)benzyloxy]-2,3-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 183164-90-1 2-[4-(4-Chlorobenzoyl)benzyloxy]-3-methylpyrido[1,2-a]pyrimidin-4-one 
• 183165-28-8 1-[4-(4-Chlorobenzoyl)benzyl]-5-methyl-1H-triazolo [4,5-d]pyridazin-4(5H)-one 
• 183165-33-5 1-[4-(4-Chlorobenzoyl)benzyl]-5-methyl-1H-pyrrolo-[2,3-d]pyridazin-4(5H)-one 
• 183165-38-0 1-[4-(4-Chlorobenzoyl)benzyl]-2,3,5-trimethyl-1H-pyrrolo [2,3-d]pyridazin-4(5H)-one 
• 183164-54-7 2-[4-(4-Chlorobenzoyl)benzyl]thio-3-methylthieno-[3,2-d]pyrimidin-4(3H)-one 
• 898769-96-5 (4-chlorophenyl){4-[(morpholin-4-yl)methyl]phenyl}methanone 
• 949934-14-9 (4-chlorophenyl)[4-(diethylaminomethyl)phenyl]methanone 
• 949934-15-0 (4-chlorophenyl){4-[1-(tert-butoxycarbonyl)piprerazin-4-ylmethyl]phenyl}methanone 
• 69677-65-2 4-chloro-4'-benzyl benzophenone 

Relevant academic research and scientific papers

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: Exploring an innovative pharmacophore

Identification of new molecular scaffolds structurally unrelated to known antimalarials may represent a valid strategy to overcome resistance of P. falciparum (Pf) to currently available drugs. We describe herein the investigation of a new polycyclic phar

Benzylated 1,2,3-triazoles as anticoccidiostats

Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s,v to 5a-s,v. In Scheme I, the brominated benzyl analogues 5 were converted to the corresponding benzyl azides 6, which were treated with cyanoacetamide to yield 1-substituted-5-amino-4-carbamoyl-1,2,3-triazoles 3. In Scheme II, the benzyl halides 5 were employed to alkylate the sodium salt of 5-amino-4-carbamoyl-1,2,3-triazole (7). Preliminary screening data against Eimeria acervulina and E. tenella in chickens suggested structural requirements for maximizing activity. Further evaluation against a relatively resistant series of eight Eimeria field isolates revealed L-651,582 (3a) to be a highly effective coccidiostat. However, unacceptable tissue residues precluded further development. Mechanistic studies on this series of 5-amino-4-carbamoyl-1,2,3-triazoles and, in particular, on L-651,582 (3a) revealed that its mode of action does not involve inhibition of IMP dehydrogenase, but probably interferes with host cell calcium entry. In addition, L-651,582 has been found to have antiproliferative activity in several disease models and was recently reported to possess antimetastatic activity in a model of ovarian cancer progression.

5-amino or substituted amino 1,2,3-triazoles

Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with a

Analogues of clofibrate and clobuzarit containing fluorine in the side chains

A series of analogues of clofibrate and 2-[4-(4-chlorophenyl)phenylmethoxy]-2-methylpropionic acid (clobuzarit) has been prepared by replacing the methyl groups by trifluoromethyl groups and changing the aromatic moiety. The activity of these compounds has been assayed on the plasma levels of cholesterol, Total Esterified Fatty Acids (T.E.F.A.) and fibrinogen in rats. It appears that derivatives of the first series which contain only one trifluoromethyl group are hypocholesterolaemic and that many mono- of bis- trifluoromethyl derivatives of the second series lower the levels of both cholesterol and T.E.F.A. in contrast to clobuzarit.