4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate
CAS No.:1429466-24-9
Molecular Formula:C₁₈H₁₅F₃O₄S
Molecular Weight:384.376
Hs Code.:

Synonyms:4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate

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Chemical Property of 4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate

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Technology Process of 4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate

There total 3 articles about 4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1429466-23-8
4-iodo-2,6-dimethylphenyl trifluoromethanesulfonate

: 10602-04-7
(4-ethynylphenyl)methanol

: 1429466-24-9
4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate

Guidance literature:: With copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2013.02.105

Reference yield:

: 10570-67-9
4-iodo-2,6-dimethylphenol

: 1429466-24-9
4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane; pyridine / 0.5 h / -10 - 40 °C

2: triethylamine; bis(triphenylphosphine)palladium(II) dichloride; copper(l) iodide / tetrahydrofuran

With copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1016/j.tetlet.2013.02.105

Reference yield:

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 1429466-24-9
4-{2-[4-(hydroxymethyl)phenyl]ethynyl}-2,6-dimethylphenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; N-iodo-succinimide / chloroform / 18 h

2: dichloromethane; pyridine / 0.5 h / -10 - 40 °C

3: triethylamine; bis(triphenylphosphine)palladium(II) dichloride; copper(l) iodide / tetrahydrofuran

With N-iodo-succinimide; copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; pyridine; dichloromethane; chloroform;
DOI:10.1016/j.tetlet.2013.02.105