N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide

Base Information

Chemical Name:N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide
CAS No.:1477751-69-1
Molecular Formula:C₂₂H₁₆ClFN₄O
Molecular Weight:406.847
Hs Code.:

Synonyms:N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide

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Chemical Property of N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide

Chemical Property:

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Technology Process of N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide

There total 5 articles about N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 153436-71-6
6-amino-4-[(3-chlorophenyl)amino]quinazoline

: 459-04-1
4-Fluorophenylacetyl chloride

: 1477751-69-1
N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide

Guidance literature:: With potassium carbonate; In ethyl acetate; at 0 ℃;
DOI:10.1039/c3ra45204b

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 1477751-69-1
N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2 h / 70 - 80 °C

2: acetic acid / 2 h / Reflux

3: acetic acid; iron / water; ethanol / 70 - 80 °C

4: potassium carbonate / ethyl acetate / 0 °C

With iron; potassium carbonate; acetic acid; In ethanol; water; ethyl acetate;
DOI:10.1039/c3ra45204b

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 1477751-69-1
N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-2-(4-fluorophenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / 80 °C

2: potassium carbonate / ethyl acetate / 0 °C

With thionyl chloride; potassium carbonate; In ethyl acetate;
DOI:10.1039/c3ra45204b