(2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde

Base Information

Chemical Name:(2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde
CAS No.:247255-18-1
Molecular Formula:C₁₄H₂₄O₃
Molecular Weight:240.343
Hs Code.:

Synonyms:(2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde

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Chemical Property of (2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde

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Technology Process of (2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde

There total 7 articles about (2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 247255-17-0
(2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propan-1-ol

: 247255-18-1
(2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde

Guidance literature:: With pyridine-SO₃ complex; In dichloromethane; dimethyl sulfoxide; triethylamine; at -12 - -6 ℃; for 2h;
DOI:10.1002/(sici)1099-0690(199908)1999:8<1803::aid-ejoc1803>3.0.co;2-l

Reference yield:

: methyl [(2R,5R)-5-isopropenyl-2-methylcyclohexyl]acetate

: 247255-18-1
(2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 91 percent / DMPU / tetrahydrofuran / 0.5 h / -78 °C

2.1: 92 percent / LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 81 percent / pyridine / 15 h / 20 °C

4.1: 58 percent / OsO₄; KIO₄ / tetrahydrofuran; H₂O / 24 h / 45 °C

5.1: 96 percent / K₂CO₃ / methanol / 40 h / 20 °C

6.1: 96 percent / PPTS / toluene / 12 h / Heating

7.1: 89 percent / SO₃*py / dimethylsulfoxide; CH₂Cl₂; triethylamine / 2 h / -12 - -6 °C

With pyridine; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; potassium metaperiodate; pyridine-SO₃ complex; pyridinium p-toluenesulfonate; potassium carbonate; diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; triethylamine; toluene; 1.1: Metallation / 1.2: Methylation / 2.1: Hydrogenolysis / 3.1: Acetylation / 4.1: Oxidation / 5.1: Deacetylation / 6.1: Condensation / 7.1: Dehydrogenation;
DOI:10.1002/(sici)1099-0690(199908)1999:8<1803::aid-ejoc1803>3.0.co;2-l

Reference yield:

: 247255-16-9
1-{(1S,3S,4R)-3-[(1R)-2-hydroxy-1-methylethyl]-4-methylcyclohexyl}ethanone

: 247255-18-1
(2R)-2-[(1S,2R,5S)-2-methyl-5-(2-methyl[1,3]dioxolan-2-yl)cyclohexyl]propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / PPTS / toluene / 12 h / Heating

2: 89 percent / SO₃*py / dimethylsulfoxide; CH₂Cl₂; triethylamine / 2 h / -12 - -6 °C

With pyridine-SO₃ complex; pyridinium p-toluenesulfonate; In dichloromethane; dimethyl sulfoxide; triethylamine; toluene; 1: Condensation / 2: Dehydrogenation;
DOI:10.1002/(sici)1099-0690(199908)1999:8<1803::aid-ejoc1803>3.0.co;2-l