tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate
CAS No.:936482-39-2
Molecular Formula:C₂₀H₂₂ClF₃N₄O₂
Molecular Weight:442.868
Hs Code.:

Synonyms:tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

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Chemical Property of tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

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Technology Process of tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

There total 5 articles about tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 882856-58-8
tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

: 1193-21-1
4,6-dichloropyrimidine

: 936482-39-2
tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: With N,N-diethyl-N-isopropylamine; In isopropyl alcohol; at 100 ℃; for 1.3h;
DOI:10.1021/jm061436d

Reference yield:

: C₁₈H₁₅F₃N₂O₃

: 936482-39-2
tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: borane dimethylsulfide complex / tetrahydrofuran / 70 °C

2: Zn; AcOH / ethanol / 75 °C

3: 3.68 g / tetrahydrofuran; CH₂Cl₂

4: 96 percent / ammonium formate; MeOH / Pd/C / 1.5 h / Heating

5: 86 percent / i-PrNEt₂ / propan-2-ol / 1.3 h / 100 °C

With methanol; N,N-diethyl-N-isopropylamine; dimethylsulfide borane complex; ammonium formate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm061436d

Reference yield:

: C₁₈H₁₇F₃N₂O₂

: 936482-39-2
tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: Zn; AcOH / ethanol / 75 °C

2: 3.68 g / tetrahydrofuran; CH₂Cl₂

3: 96 percent / ammonium formate; MeOH / Pd/C / 1.5 h / Heating

4: 86 percent / i-PrNEt₂ / propan-2-ol / 1.3 h / 100 °C

With methanol; N,N-diethyl-N-isopropylamine; ammonium formate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm061436d