tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

Base Information

• Chemical Name: tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate
• CAS No.: 882856-58-8
• Molecular Formula: C₁₆H₂₁F₃N₂O₂
• Molecular Weight: 330.35
• Mol file: 882856-58-8.mol

Synonyms:tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

Chemical Property of tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

There total 16 articles about tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl (3R,4R)-1-benzyl-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate (882856-76-0) → tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate (882856-58-8)

Guidance literature:

With methanol; ammonium formate; palladium on activated charcoal; for 1.5h; Heating;

DOI:10.1021/jm061436d

Reference yield:

C18H15F3N2O3 → tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate (882856-58-8)

Guidance literature:

Multi-step reaction with 4 steps

1: borane dimethylsulfide complex / tetrahydrofuran / 70 °C

2: Zn; AcOH / ethanol / 75 °C

3: 3.68 g / tetrahydrofuran; CH₂Cl₂

4: 96 percent / ammonium formate; MeOH / Pd/C / 1.5 h / Heating

With methanol; dimethylsulfide borane complex; ammonium formate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm061436d

Reference yield:

C18H17F3N2O2 → tert-butyl(3R,4R)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate (882856-58-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Zn; AcOH / ethanol / 75 °C

2: 3.68 g / tetrahydrofuran; CH₂Cl₂

3: 96 percent / ammonium formate; MeOH / Pd/C / 1.5 h / Heating

With methanol; ammonium formate; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm061436d

upstream raw materials:

tert-butyl (3R,4R)-1-benzyl-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

ethyl 3-(2,4,5-trifluorophenyl)acrylate

dimethyl 2-cyano-3-(2,4,5-trifluorophenyl)pentanedioate

2,4,5-trifluorobenzaldehyde

Downstream raw materials:

tert-butyl (3R,4R)-1-(6-chloropyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

tert-butyl(3R,4R)-1-(4-chloro-1,3,5-triazin-2-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

tert-butyl [(3R,4R)-1-[(6-methylamino)-5-nitropyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

tert-butyl [(3R,4R)-1-[6-(aminocarbonyl)-5-nitropyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate