4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Name:4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No.:1350852-33-3
Molecular Formula:C₂₇H₁₈ClF₃N₆O
Molecular Weight:534.928
Hs Code.:

Synonyms:4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

There total 5 articles about 4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350855-86-5
4-amino-2-{(2Z)-2-[1-(2-bromo-5-chlorophenyl)-2-(2,3,6-trifluorophenyl)ethylidene]hydrazinyl}-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 1350852-33-3
4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: With copper(l) iodide; N,N`-dimethylethylenediamine; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 1h; Inert atmosphere;

Reference yield:

: 27007-53-0
methyl-2-bromo-5-chlorobenzoate

: 1350852-33-3
4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / methanol / 4 h / 100 °C / Inert atmosphere

3: sodium hydrogencarbonate / methanol / 0.67 h / 135 °C / Inert atmosphere; microwave irradiation

4: copper(l) iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 1 h / 18 - 25 °C / Inert atmosphere

With copper(l) iodide; boron trifluoride diethyl etherate; sodium hexamethyldisilazane; sodium hydrogencarbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 114152-23-7
2-(2,3,6-trifluorophenyl)acetic acid

: 1350852-33-3
4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-methyl-5-phenyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / methanol / 4 h / 100 °C / Inert atmosphere

3: sodium hydrogencarbonate / methanol / 0.67 h / 135 °C / Inert atmosphere; microwave irradiation

4: copper(l) iodide; N,N`-dimethylethylenediamine / N,N-dimethyl-formamide / 1 h / 18 - 25 °C / Inert atmosphere

With copper(l) iodide; boron trifluoride diethyl etherate; sodium hexamethyldisilazane; sodium hydrogencarbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;