AZD₂₂₈₁-Tz

Base Information

• Chemical Name: AZD₂₂₈₁-Tz
• CAS No.: 1286255-39-7
• Molecular Formula: C₃₄H₃₂FN₉O₄
• Molecular Weight: 649.684
• Mol file: 1286255-39-7.mol

Synonyms:AZD₂₂₈₁-Tz

Chemical Property of AZD₂₂₈₁-Tz

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AZD₂₂₈₁-Tz

There total 3 articles about AZD₂₂₈₁-Tz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine hydrochloride (1092689-33-2) + C25H25FN4O5 → AZD2281-Tz (1286255-39-7)

Guidance literature:

C₂₅H₂₅FN₄O₅; In dichloromethane; at 20 ℃; for 7h;

(4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine hydrochloride; With triethylamine; In dichloromethane; for 1h;

Reference yield:

4-[4’’-fluoro-3’’-(piperazine-1’’’-carbonyl)benzyl]-2H-phthalazin-1-one (763111-47-3) → AZD2281-Tz (1286255-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h

2.1: cyclohexylcarbodiimide polystyrene resin / dichloromethane / 7 h / 20 °C

2.2: 1 h

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

glutaric anhydride, (108-55-4) → AZD2281-Tz (1286255-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h

2.1: cyclohexylcarbodiimide polystyrene resin / dichloromethane / 7 h / 20 °C

2.2: 1 h

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

upstream raw materials:

4-[4’’-fluoro-3’’-(piperazine-1’’’-carbonyl)benzyl]-2H-phthalazin-1-one

glutaric anhydride,

(4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine hydrochloride

Refernces