2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid

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Chemical Name:2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid
CAS No.:143782-21-2
Molecular Formula:C₁₅H₁₂F₃N₃O₄
Molecular Weight:355.273
Hs Code.:

Synonyms:2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid

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Chemical Property of 2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid

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Technology Process of 2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid

There total 5 articles about 2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 143782-22-3
2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate

: 143782-21-2
2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid

Guidance literature:: With sodium hydroxide; In methanol; at 50 ℃; for 2h;
DOI:10.1021/acs.inorgchem.8b00083

Reference yield:

: 79-08-3
bromoacetic acid

: 143782-20-1
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 143782-21-2
2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid

Guidance literature:: With hydrogenchloride; In N-methyl-acetamide; water;

Reference yield:

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 143782-21-2
2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 45 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

2.2: 5 h / 55 °C / Inert atmosphere

3.1: sodium hydroxide / methanol / 2 h / 50 °C

With sodium hydride; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.inorgchem.8b00083