2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate

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Chemical Name:2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate
CAS No.:143782-22-3
Molecular Formula:C₁₇H₁₆F₃N₃O₄
Molecular Weight:383.327
Hs Code.:

Synonyms:2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate

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Chemical Property of 2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate

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Technology Process of 2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate

There total 4 articles about 2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 105-36-2
ethyl bromoacetate

: 143782-20-1
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 143782-22-3
2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate

Guidance literature:: 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

ethyl bromoacetate; In N,N-dimethyl-formamide; mineral oil; at 55 ℃; for 5h; Inert atmosphere;
DOI:10.1021/acs.inorgchem.8b00083

Reference yield:

: potassium phosphate

: 105-36-2
ethyl bromoacetate

: 143782-20-1
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 143782-22-3
2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate

Guidance literature:: In N-methyl-acetamide; ice-water;

Reference yield:

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 143782-22-3
2-(5,5-dimethyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-2,4-dioxoimidazolin-1-yl) ethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 45 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

2.2: 5 h / 55 °C / Inert atmosphere

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.inorgchem.8b00083