1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

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Chemical Name:1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide
CAS No.:637319-09-6
Molecular Formula:C₂₅H₁₉F₄N₃O₄S
Molecular Weight:533.503
Hs Code.:

Synonyms:1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

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Chemical Property of 1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

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Technology Process of 1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

There total 10 articles about 1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₂₅F₄N₃O₇S

: 637319-09-6
1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 18h;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 637319-09-6
1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 100 percent / 2 h / 20 °C

4: KMnO₄ / acetone; H₂O / 4 h / Heating

5: oxalyl chloride / CH₂Cl₂ / 2 h / 20 °C

6: 3.34 g / DMAP / CH₂Cl₂ / 18 h / 20 °C

7: 89 percent / aq. NaOH / methanol / 5 h / 20 °C

8: N-methylmorpholine / tetrahydrofuran / 1 h / -10 °C

9: 0.56 g / NaBH₄ / tetrahydrofuran; H₂O / 18 h / 20 °C

With 4-methyl-morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/jm030212h

Reference yield:

: 5326-27-2
2-hydrazino-benzoic acid

: 637319-09-6
1-(2-hydroxymethyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 100 percent / 2 h / 20 °C

4: KMnO₄ / acetone; H₂O / 4 h / Heating

5: oxalyl chloride / CH₂Cl₂ / 2 h / 20 °C

6: 3.34 g / DMAP / CH₂Cl₂ / 18 h / 20 °C

7: 89 percent / aq. NaOH / methanol / 5 h / 20 °C

8: N-methylmorpholine / tetrahydrofuran / 1 h / -10 °C

9: 0.56 g / NaBH₄ / tetrahydrofuran; H₂O / 18 h / 20 °C

With 4-methyl-morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/jm030212h